A number of calls for doctoral students of the Doctoral School as part of the project “jUSt transition – The potential of the University of Silesia as the basis for the Just Transformation of the region” have been open.

On 27.01.2025-28.02.2025, recruitment is being conducted for:

Foreign trips within Europe – announcement.

Foreign trips outside Europe – announcement.

Trips to foreign scientific conferences – announcement.

Funding for research conducted by doctoral students up to PLN 5,000 – announcement.

A doctoral student can obtain funding in the program only once in each type of call (trips 1-3 are treated as one category).

The condition for obtaining funding is the presentation by the supervisor of confirmation that the doctoral student has entered the project criteria.

More about the “jUSt transition” program – https://just.fesl.us.edu.pl/

We encourage you to read the announcement of a competition for doctoral students of the Doctoral School for funds for scientific activity. Applications for the call can be submitted until October 20 and may cover expenses to be completed by the end of 2021.

More about the competition: https://us.edu.pl/szkola-doktorska/en/srodki-na-dzialalnosc-naukowa-doktorantow/konkurs-dla-doktorantow-srodki-na-dzialalnosc-naukowa/

Project description:

The goal of this project is to investigate the impact of chelators with the ability to inhibit tyrosine kinases on key cellular processes. This project focuses on one of the most aggressive cancer, glioblastoma multiforme (GBM). The epidermal growth factor receptor (EGFR) belongs to the receptor tyrosine kinases (RTKs) family. The presence of mutations in the EGFR region results in increased proliferation and resistance to therapy with older generation of the tyrosine kinase inhibitors (TKIs). One of the most common mutation in the extracellular domain of the EGFR receptor is EGFR variant III (EGFRvIII), characteristic of GBM. It is also worth mentioning that the current knowledge of GBM has many gaps in understanding the origin of the tumor, its heterogeneity and the specificity of the surrounding tissues. Therefore, in the current project, we plan to perform experiments on patient-derived cell lines and 3D spheroid models that reflect the actual tumor conditions. GBM therapy faces the problem of the insufficient drug penetration through the blood-brain barrier. Currently, only osimertinib is a third-generation EGFR inhibitor that penetrates the blood-brain barrier. Iron metabolism is closely related to the EGFR pathway, which seems to be particularly important in the development of GBM. Based on our previous experience, we designed novel multi-targeted drugs (named FeTKIs) by combining iron (Fe) chelation functionality with tyrosine kinase inhibition (TKI). FeTKIs are novel osimertinib analogs with the potential to inhibit EGFR and the ability to bind iron ions. We suggest that this approach will impact several molecular targets and aspects of GBM treatment.

In this project, the PhD student will perform the following research tasks:

• investigation of the cellular response to the incubation with FeTKIs, which are characterized by good metal ion chelating ability, EGFR inhibition and sufficient penetration of the blood-brain barrier
• testing the specificity of FeTKIs against EGRFvIII mutation
• comparison of the results obtained on commercially available cell lines with cells derived from patients (studies on traditional monolayer cultures and 3D spheroids)

Requirements:

1. MSc diploma in biotechnology, biology, biophysics, medical physics, medicinal chemistry or related science.
2. Knowledge of the basic cell biology and human genetics and molecular biology.
3. Experience in cell culture, PCR, RT-qPCR, ELISA, flow cytometry or Western Blot is welcome.
4. Good written and oral communication skills in English.
5. High motivation to conduct scientific research and ability to work in a team.
6. Scientific achievements, especially papers published in science journals and conference presentations will be an additional asset.

Required documents:

1. Motivation list with a description of the scientific interests
2. CV
3. List of scientific publications
4. Copy of the MSc diploma
5. Recommendation opinion from current supervisor

Formal requirements:

Candidates should register in IRK system and select „ Doctoral School – admission by grant and implementation doctorate program”. https://irk.us.edu.pl/

Documents should be delivered till 31.08.2021  to an e-mail: anna.mrozek-wilczkiewicz@us.edu.pl

In case of any questions, before the formal application please contact to the grant leader for the e-mail address given above.

Documents will be rated by the commission, led by the project leader. Admission will be carried out according to the NCN regulations. Admission can be carried out both in Polish and in English. Meeting will be organized on 06.09.2021  in the Doctoral School office / on-line. Final decision will be sent to candidates via e-mail till 07.09.2021.

PhD student in the Doctoral School – call for applications

Position: PhD student in Earth Sciences discipline

Unit of the project realization: Faculty of Natural Sciences – University of Silesia in Katowice

Unit realizing the PhD student education: Doctoral School at the University of Silesia in Katowice

A PhD student, through his/her work on the PhD project, will actively support the main scientific aims of Biomorphodynamics of Mountain Geoecosystem Research Team. A PhD student will be responsible for systematic research and production of high-quality results, their publication and presentation during domestic and international conferences.

Research will be carried out in the frame of the project of Preludium-BIS, financed from NCN sources, entitled: „BIOFORCLIM – biomorphodynamics of forested hillslopes driven by forest ecosystem disturbances due to hurricane wind events and their relation to changing climate conditions ” (number 2019/35/O/ST10/00032) under supervision of Łukasz Pawlik, PhD, associate professor.

Project description:

Damage caused by hurricane wind in old-growth and managed forests may have their geomorphic consequences. It is mainly due to windthrows when trees are uprooted and some part of soil material attached to root systems is relocated. This factor in many geomorphic and soil studies was neglected and in consequence, for many protected forest ecosystems, the process of windthrows occurrence stayed significantly understudied. It applies to the current activity of the process and its long-term dynamics during the past several hundred years.

One of the natural archives that record the scope of wind damages in forests is tree-rings. A significant increase of the tree-rings width during the subsequent 5-10 years can be interpreted as an increase in solar radiation availability for trees growing under a closed forest canopy. Such a situation may occur when a gap in the forest canopy is formed by a fallen tree (uprooted or broken). One of the aims of the present project is quantification and characteristic of the contemporaneous wind regime of national parks selected for this study but also a description of the intensity and effectiveness of soil material biotransport induced by the tree uprooting process. The database created during the project realization will allow indicating which are primary factors influencing the range of this kind of biotransport. This information will be used to biotransport modeling modified by forest stand features, topography and wind regime of the sites.

A PhD student will be responsible for all aspects of the study including fieldwork and theoretical analyses. The main tasks between others include 1) preparation of an extensive database, based on the archive and historical resources, with information on the past wind-related damage of forest ecosystems in three national parks, 2) tree cores sampling, measurement of tree-rings and their statistical analysis, 3) time series analysis allowing deep characterization of wind regime of the study sites. A PhD student will be obliged to publish his/her study results in the English language in the most prestigious scientific journals.

Requirements:

1. MSc diploma in geomorphology, physical geography, meteorology, climatology, GIS, cartography, geology, geophysics or similar.
2. Good and practical knowledge of the English language (written and spoken).
3. Good knowledge and practical skills in programming and/or statistical analyses (in R or Python), or willingness and ability to learn one of these programs.
4. Good knowledge and practical skills of GIS (Geographic Information System) software (SAGA GIS, QGIS, or ArcGIS), or willingness and ability to learn one of these GIS platforms.
5. Knowledge on dendrochronology will be an additional advantage.
6. High motivation and no formal contraindications for a 6-month scholarship at the University of Colorado in Denver, USA.
7. High motivation to realize the scientific investigations coupled with ability to work in a team
8. Documented scientific achievements in Earth Sciences (preferred co-authorship of the paper published in a journal from the so-called Filadelphian List), experience in presentation of the results during conferences will be an additional advantage.

Required documents:

1. Motivation letter with a description of the scientific interests
2. CV
3. List of scientific publications with per-cent of the contribution of the candidate
4. Copy of the MSc diploma
5. Two professional references.

Candidates should register in IRK system and select „Doctoral School – admission to a grant” (https://irk.us.edu.pl/, accessible from 15.07.2020).

Documents should be delivered till 25.09.2020 to an e-mail: lukasz.pawlik@us.edu.pl.

In case of any questions, before the formal application please contact to the grant leader for the e-mail address given above.

Documents will be rated by the commission, led by the project leader. Admission will be carried out according to the NCN regulations. Admission can be carried out both in Polish and in English. Meeting will be organized on 28.09.2020 in the Doctoral School office (or on-line). Final decision will be sent to candidates via e-mail till 29.09.2020.