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<\/center><\/p>\n<\/div>\r\n <\/div>\r\n <\/div>[\/vc_column][\/vc_row][vc_row][vc_column]\r\n DISCIPLINE – CHEMISTRY
\nTYPE OF STUDY – ONLINE LECTURES
\n<\/span><\/h3>\n\n<\/div>\r\n <\/div>\r\n <\/div>[\/vc_column][\/vc_row][vc_row el_class=”container”][vc_column][vc_btn title=”Edition 2023″ style=”outline-custom” outline_custom_color=”#9b132a” outline_custom_hover_background=”#9b132a” outline_custom_hover_text=”#ffffff” shape=”square” size=”lg” align=”center” button_block=”true”][vc_tta_accordion color=”white” c_icon=”triangle” active_section=”10″ no_fill=”true” collapsible_all=”true” el_id=”zmiana-koloru” css=”.vc_custom_1667723845346{background-color: #ffffff !important;}”][vc_tta_section title=”Catalytic and photolytic properties of vitamin B12 derivatives” tab_id=”1667723775224-1dfcca89-8c0b”]\r\n
\r\n \r\n \r\n <\/p>\n\n- Vitamin B12<\/sub> and its historical significance; biologically active forms of vitamin B12<\/sub>; adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl)-dependent enzymes and their catalytic functions (1hr);<\/li>\n
- Photochemistry of vitamin B12<\/sub> derivatives from historical perspective; alkyl vs. non-alkyl cobalamins; base-on vs. base-off conformations; triplet states (1hr);<\/li>\n
- Computational approach; modeling structural and electronic properties of cobalamins in solution and inside enzymatic environment; activation of Co-C bond (1hr);<\/li>\n
- Photochemistry of B12<\/sub>-dependent enzymes such as EAL and GLM or MetH and MetH with mutation; photoreceptor CarH (1hr).<\/li>\n<\/ol>\n
\n<\/div>\r\n <\/div>\r\n <\/div>[\/vc_tta_section][vc_tta_section i_type=”material” i_icon_material=”vc-material vc-material-fiber_new” add_icon=”true” title=”Vitamins” tab_id=”1673212003851-1502a46c-491d”]\r\n
\r\n \r\n \r\n Water and lipid soluble vitamins (vitamins A, B<\/span><\/span>1<\/span><\/span><\/sub>, B<\/span><\/span>2<\/span><\/span><\/sub>, B<\/span><\/span>3<\/span><\/span><\/sub>, B<\/span><\/span>5<\/span><\/span><\/sub>, B<\/span><\/span>6<\/span><\/span><\/sub>, B<\/span><\/span>9<\/span><\/span><\/sub>, B<\/span><\/span>12<\/span><\/span><\/sub>, C, D, E, H and K) and derived aspects (occurrence, physiological importance, symptoms of insufficiency, toxicity).<\/span><\/span>\u00a0<\/span><\/p>\n<\/div>\r\n <\/div>\r\n <\/div>[\/vc_tta_section][\/vc_tta_accordion][vc_empty_space height=”4″ css=”.vc_custom_1673212309433{background-color: #002e5a !important;}”][vc_empty_space][vc_btn title=”Edition 2022″ style=”outline-custom” outline_custom_color=”#9b132a” outline_custom_hover_background=”#9b132a” outline_custom_hover_text=”#ffffff” shape=”square” size=”lg” align=”center” button_block=”true”][vc_tta_accordion color=”white” c_icon=”triangle” active_section=”10″ no_fill=”true” collapsible_all=”true” el_id=”zmiana-koloru” css=”.vc_custom_1672668333194{background-color: #ffffff !important;}”][vc_tta_section title=”Catalytic and photolytic properties of vitamin B12 derivatives” tab_id=”1672668218475-0c872e3d-041e”]\r\n \r\n \r\n \r\n <\/p>\n\n- Vitamin B12<\/sub> and its historical significance; biologically active forms of vitamin B12<\/sub>; adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl)-dependent enzymes and their catalytic functions (1hr);<\/li>\n
- Photochemistry of vitamin B12<\/sub> derivatives from historical perspective; alkyl vs. non-alkyl cobalamins; base-on vs. base-off conformations; triplet states (1hr);<\/li>\n
- Computational approach; modeling structural and electronic properties of cobalamins in solution and inside enzymatic environment; activation of Co-C bond (1hr);<\/li>\n
- Photochemistry of B12<\/sub>-dependent enzymes such as EAL and GLM or MetH and MetH with mutation; photoreceptor CarH (1hr).<\/li>\n<\/ol>\n
\n<\/div>\r\n <\/div>\r\n <\/div>[\/vc_tta_section][vc_tta_section title=”Computational modeling of bioinorganic systems” tab_id=”1672668218488-45a943d4-4f4a”]\r\n
\r\n \r\n \r\n <\/p>\n\n- Role of metals in biology; introduction to electronic structure of transition metals and ligand field theory; structure of metalloproteins (1hr);<\/li>\n
- Protein Data Bank (PDB) as resource for chemical, biochemical, and structural explorations of biomolecules with transition metals; heme-containing metalloproteins, non-heme systems, B12<\/sub>-dependent enzymes (1hr);<\/li>\n
- Introduction to molecular mechanics (MM), Density Functional Theory (DFT) and combined QM\/MM approach to elucidate structure, reactivity and spectroscopic properties of metalloproteins (1hr);<\/li>\n
- Reaction pathways; location of transition states (TSs); spectroscopic properties of selected metalloenzymes (1hr).<\/li>\n<\/ol>\n
\n<\/div>\r\n <\/div>\r\n <\/div>[\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]<\/p>","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row el_class=”container”][vc_column][vc_btn title=”Edition 2023″ style=”outline-custom” outline_custom_color=”#9b132a” outline_custom_hover_background=”#9b132a” outline_custom_hover_text=”#ffffff” shape=”square” size=”lg” align=”center” button_block=”true”][vc_tta_accordion color=”white” c_icon=”triangle” active_section=”10″ no_fill=”true” collapsible_all=”true” el_id=”zmiana-koloru” css=”.vc_custom_1667723845346{background-color: #ffffff !important;}”][vc_tta_section title=”Catalytic and photolytic properties of vitamin B12 derivatives” tab_id=”1667723775224-1dfcca89-8c0b”][\/vc_tta_section][vc_tta_section i_type=”material” i_icon_material=”vc-material vc-material-fiber_new” add_icon=”true” title=”Vitamins” tab_id=”1673212003851-1502a46c-491d”][\/vc_tta_section][\/vc_tta_accordion][vc_empty_space height=”4″ css=”.vc_custom_1673212309433{background-color: #002e5a !important;}”][vc_empty_space][vc_btn title=”Edition 2022″ style=”outline-custom” outline_custom_color=”#9b132a” outline_custom_hover_background=”#9b132a” outline_custom_hover_text=”#ffffff” shape=”square” size=”lg” align=”center” button_block=”true”][vc_tta_accordion color=”white” c_icon=”triangle” active_section=”10″ no_fill=”true” collapsible_all=”true” […]<\/p>\n
- \n
- Vitamin B12<\/sub> and its historical significance; biologically active forms of vitamin B12<\/sub>; adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl)-dependent enzymes and their catalytic functions (1hr);<\/li>\n
- Photochemistry of vitamin B12<\/sub> derivatives from historical perspective; alkyl vs. non-alkyl cobalamins; base-on vs. base-off conformations; triplet states (1hr);<\/li>\n
- Computational approach; modeling structural and electronic properties of cobalamins in solution and inside enzymatic environment; activation of Co-C bond (1hr);<\/li>\n
- Photochemistry of B12<\/sub>-dependent enzymes such as EAL and GLM or MetH and MetH with mutation; photoreceptor CarH (1hr).<\/li>\n<\/ol>\n
\n<\/div>\r\n <\/div>\r\n <\/div>[\/vc_tta_section][vc_tta_section i_type=”material” i_icon_material=”vc-material vc-material-fiber_new” add_icon=”true” title=”Vitamins” tab_id=”1673212003851-1502a46c-491d”]\r\n
\r\n\r\n \r\nWater and lipid soluble vitamins (vitamins A, B<\/span><\/span>1<\/span><\/span><\/sub>, B<\/span><\/span>2<\/span><\/span><\/sub>, B<\/span><\/span>3<\/span><\/span><\/sub>, B<\/span><\/span>5<\/span><\/span><\/sub>, B<\/span><\/span>6<\/span><\/span><\/sub>, B<\/span><\/span>9<\/span><\/span><\/sub>, B<\/span><\/span>12<\/span><\/span><\/sub>, C, D, E, H and K) and derived aspects (occurrence, physiological importance, symptoms of insufficiency, toxicity).<\/span><\/span>\u00a0<\/span><\/p>\n<\/div>\r\n <\/div>\r\n <\/div>[\/vc_tta_section][\/vc_tta_accordion][vc_empty_space height=”4″ css=”.vc_custom_1673212309433{background-color: #002e5a !important;}”][vc_empty_space][vc_btn title=”Edition 2022″ style=”outline-custom” outline_custom_color=”#9b132a” outline_custom_hover_background=”#9b132a” outline_custom_hover_text=”#ffffff” shape=”square” size=”lg” align=”center” button_block=”true”][vc_tta_accordion color=”white” c_icon=”triangle” active_section=”10″ no_fill=”true” collapsible_all=”true” el_id=”zmiana-koloru” css=”.vc_custom_1672668333194{background-color: #ffffff !important;}”][vc_tta_section title=”Catalytic and photolytic properties of vitamin B12 derivatives” tab_id=”1672668218475-0c872e3d-041e”]\r\n
\r\n\r\n \r\n<\/p>\n- \n
- Vitamin B12<\/sub> and its historical significance; biologically active forms of vitamin B12<\/sub>; adenosylcobalamin (AdoCbl) and methylcobalamin (MeCbl)-dependent enzymes and their catalytic functions (1hr);<\/li>\n
- Photochemistry of vitamin B12<\/sub> derivatives from historical perspective; alkyl vs. non-alkyl cobalamins; base-on vs. base-off conformations; triplet states (1hr);<\/li>\n
- Computational approach; modeling structural and electronic properties of cobalamins in solution and inside enzymatic environment; activation of Co-C bond (1hr);<\/li>\n
- Photochemistry of B12<\/sub>-dependent enzymes such as EAL and GLM or MetH and MetH with mutation; photoreceptor CarH (1hr).<\/li>\n<\/ol>\n
\n<\/div>\r\n <\/div>\r\n <\/div>[\/vc_tta_section][vc_tta_section title=”Computational modeling of bioinorganic systems” tab_id=”1672668218488-45a943d4-4f4a”]\r\n
\r\n\r\n \r\n<\/p>\n- \n
- Role of metals in biology; introduction to electronic structure of transition metals and ligand field theory; structure of metalloproteins (1hr);<\/li>\n
- Protein Data Bank (PDB) as resource for chemical, biochemical, and structural explorations of biomolecules with transition metals; heme-containing metalloproteins, non-heme systems, B12<\/sub>-dependent enzymes (1hr);<\/li>\n
- Introduction to molecular mechanics (MM), Density Functional Theory (DFT) and combined QM\/MM approach to elucidate structure, reactivity and spectroscopic properties of metalloproteins (1hr);<\/li>\n
- Reaction pathways; location of transition states (TSs); spectroscopic properties of selected metalloenzymes (1hr).<\/li>\n<\/ol>\n
\n<\/div>\r\n <\/div>\r\n <\/div>[\/vc_tta_section][\/vc_tta_accordion][\/vc_column][\/vc_row]<\/p>","protected":false},"excerpt":{"rendered":"
[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row el_class=”container”][vc_column][vc_btn title=”Edition 2023″ style=”outline-custom” outline_custom_color=”#9b132a” outline_custom_hover_background=”#9b132a” outline_custom_hover_text=”#ffffff” shape=”square” size=”lg” align=”center” button_block=”true”][vc_tta_accordion color=”white” c_icon=”triangle” active_section=”10″ no_fill=”true” collapsible_all=”true” el_id=”zmiana-koloru” css=”.vc_custom_1667723845346{background-color: #ffffff !important;}”][vc_tta_section title=”Catalytic and photolytic properties of vitamin B12 derivatives” tab_id=”1667723775224-1dfcca89-8c0b”][\/vc_tta_section][vc_tta_section i_type=”material” i_icon_material=”vc-material vc-material-fiber_new” add_icon=”true” title=”Vitamins” tab_id=”1673212003851-1502a46c-491d”][\/vc_tta_section][\/vc_tta_accordion][vc_empty_space height=”4″ css=”.vc_custom_1673212309433{background-color: #002e5a !important;}”][vc_empty_space][vc_btn title=”Edition 2022″ style=”outline-custom” outline_custom_color=”#9b132a” outline_custom_hover_background=”#9b132a” outline_custom_hover_text=”#ffffff” shape=”square” size=”lg” align=”center” button_block=”true”][vc_tta_accordion color=”white” c_icon=”triangle” active_section=”10″ no_fill=”true” collapsible_all=”true” […]<\/p>\n
- Photochemistry of vitamin B12<\/sub> derivatives from historical perspective; alkyl vs. non-alkyl cobalamins; base-on vs. base-off conformations; triplet states (1hr);<\/li>\n
- Photochemistry of vitamin B12<\/sub> derivatives from historical perspective; alkyl vs. non-alkyl cobalamins; base-on vs. base-off conformations; triplet states (1hr);<\/li>\n